Sander Bollen

…a young bioinformatician and molecular biologist.

I make sense of the vast amounts of garbled data modern biology produces.

Find me here!

  • NAMESander Bollen
  • AGE26
  • BIRTH PLACEHeerlen, Netherlands
  • ADDRESSThe Hague, Netherlands
  • E-MAILsander [AT] sndrtj [DOT] eu
  • PHONE+31 6 2125 4645

Sander Bollen


Bioinformatician2014 – now

Leiden University Medical Center

Bioinformatician at the department of Clinical Genetics at Leiden University Medical Center, in Leiden, the Netherlands. Here, I build and maintain Next Generation Sequencing pipelines for diagnostics. Some technologies used:

  • GNU Make, SnakeMake and GATK Queue
  • A lot of python
  • Javascript
  • Scala
  • Samtools
  • GATK

Intern2012 – 2013

Max Delbrück Center for Molecular Medicine

Master internship at the Computational Biology and Data Mining Group at the Max Delbrück Center for Molecular Biology in Berlin as part of my Master studies. I developed an R package called CAFE for the analysis of chromosomal abnormalities using Affymetrix microarray expression data as input. CAFE includes a range of plotting tools for easy visualization of detected abnormalities, and runs on Linux, Mac and Windows. An article describing CAFE is currently in press in Bioinformatics. Technologies learned during this internship include:

  • R, with special priority to the following packages:
    • ggplot2
    • affy
    • shiny
  • git
  • LaTeX
  • Python

Intern2011 – 2012

University Medical Center Utrecht

Master internship at the department of Medical Oncology at the lab of Susanne Lens, as part of Master studies. Investigated the spatial localization of the Chromosomal Passenger Complex onto chromosomal arms. Techniques learned during this internship include:

  • Tissue Culture
  • PCR
  • Cloning
  • Western Blots
  • Immunoprecipitation
  • Immunofluorescence Microscopy
  • Confocal Microscopy

Intern2010 – 2011

Leiden University

Internship as researcher at the department of Molecular Genetics at the lab of Remus Dame, as part of bachelor studies. Conducted research on chromatin condensation. Techniques learned during this internship include:

  • Tethered Particle Motion
  • Atomic Force Microscopy
  • Cloning
  • PCR

Intern2009 – 2010

Erasmus Medical Center

Internship as researcher at the department of Pediatrics Oncology at the lab of Ronald Stam, as part of bachelor studies. Conducted research on apoptosis inhibition in MLL-rearranged infant acute lymphoblastic leukemia. Techniques learned during this internship include:

  • RT-PCR
  • Western blot
  • Tissue Culture
  • RNA Interference


Master Biomedical Sciences2011 – 2014

Utrecht University

Master of Sciences in Biomedical Sciences with specialization in Cancer Genomics & Developmental Biology at Utrecht University, Utrecht, the Netherlands. Graduated in April 2014.

Biomedical Sciences2007 – 2011

Zuyd University

Bachelor of Applied Sciences in Biomedical Sciences at Zuyd University in Heerlen, the Netherlands. Four year programme. First two years mixed with Chemistry and Chemical Technology. Graduated in July 2011.

Development Skills







Lab Skills

Tissue culture

Confocal microscopy


Western blotting


Language Skills

Dutch (native)

English (near-native)





Sander Bollen

CAFE: an R package for the detection of gross chromosomal abnormalities from gene expression microarray data.
Sander Bollen, Mathias Leddin, Miguel A Andrade-Navarro, Nancy Mah
Bioinformatics. In press, 2014.

CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
Edze R Westra, Paul BG Erp, Tim Künne, Shi Pey Wong, Raymond HJ Staals, Christel LC Seegers, Sander Bollen,Matthijs M Jore, Ekaterina Semenova, Konstantin Severinov
Molecular cell 46.5 (2012) pp. 595–605. Elsevier, 2012

Sander Bollen

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