I make sense of the vast amounts of garbled data modern biology produces.
Bioinformatician at the department of Clinical Genetics at Leiden University Medical Center, in Leiden, the Netherlands. Here, I build and maintain Next Generation Sequencing pipelines for diagnostics. Some technologies used:
Master internship at the Computational Biology and Data Mining Group at the Max Delbrück Center for Molecular Biology in Berlin as part of my Master studies. I developed an R package called CAFE for the analysis of chromosomal abnormalities using Affymetrix microarray expression data as input. CAFE includes a range of plotting tools for easy visualization of detected abnormalities, and runs on Linux, Mac and Windows. An article describing CAFE is currently in press in Bioinformatics. Technologies learned during this internship include:
Master internship at the department of Medical Oncology at the lab of Susanne Lens, as part of Master studies. Investigated the spatial localization of the Chromosomal Passenger Complex onto chromosomal arms. Techniques learned during this internship include:
Internship as researcher at the department of Molecular Genetics at the lab of Remus Dame, as part of bachelor studies. Conducted research on chromatin condensation. Techniques learned during this internship include:
Internship as researcher at the department of Pediatrics Oncology at the lab of Ronald Stam, as part of bachelor studies. Conducted research on apoptosis inhibition in MLL-rearranged infant acute lymphoblastic leukemia. Techniques learned during this internship include:
Master of Sciences in Biomedical Sciences with specialization in Cancer Genomics & Developmental Biology at Utrecht University, Utrecht, the Netherlands. Graduated in April 2014.
Bachelor of Applied Sciences in Biomedical Sciences at Zuyd University in Heerlen, the Netherlands. Four year programme. First two years mixed with Chemistry and Chemical Technology. Graduated in July 2011.
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
Edze R Westra, Paul BG Erp, Tim Künne, Shi Pey Wong, Raymond HJ Staals, Christel LC Seegers, Sander Bollen,Matthijs M Jore, Ekaterina Semenova, Konstantin Severinov
Molecular cell 46.5 (2012) pp. 595–605. Elsevier, 2012